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Prodrugs containing chemical modifications such as reversible methylation could enhance neurotoxin lipophilicity, consequently leading to improved passive diffusion rates through the perineurium and BNB

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This led to a rise in GSH turnover and a decrease in γ-glutamyl transpeptidase (γ-GT: GSH + amino acid + H 2 O) and 3L γ-glutamyl-amino acid (L-glutamate)