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UGT activity is supported by the cofactor UDP-glucuronic acid (uridine-5′-diphospho-α-D-glucuronic acid) that is synthesized from glucose-1-phosphate and uridine triphosphate via the sequential actions of UDP-glucose pyrophosphorylase (EC 2.7.7.9) and UDP-glucose dehydrogenase (EC 1.1.1.22)