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Retatrutide targets GLP‑1 + GIP + glucagon, so some commentators have started calling it “GLP‑3” to suggest a third‑generation medication.​ How Retatrutide Works: Triple Agonist Mechanism Retatrutide is being developed as a once‑weekly injectable that activates GLP‑1, GIP, and glucagon receptors at the same time to influence appetite, blood sugar, and energy expenditure.​ GLP‑1 receptor activation Reduces appetite and food intake