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DAA, particularly neurotoxic C3 + reactive astrocytes, can be induced by factors such as IL-1α, TNF-α, and C1q, released from activated neuroinflammatory microglia, as mentioned (Liddelow et al., 2017)

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[DOI] [PubMed] [Google Scholar] 106.Siddiqui M.H., Al-Whaibi M.H