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Unfortunately, most studies in the field suffer from the shared shortcoming of small sample sizes, insufficient follow-up periods, and predominantly Chinese study cohorts, restricting their generalizability

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24 h (h) after instillation, a significant increase in cytotoxicity was observed in the 10%, 25%, 50%, and 100% CSE treated conditions compared to the respective 0% CSE control samples in dynamic conditions only (Supplementary Fig