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Consistent with this, a clinical trial investigating oral butyrate supplementation in rat models of colitis demonstrated a significant reduction in messenger RNA expression of pro inflammatory cytokines such as interleukin 6, tumor necrosis factor alpha, and interleukin 1 beta, together with inhibition of mitochondrial reactive oxygen species production (58)

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[DOI] [PubMed] [Google Scholar] 54.Sworder B.J., Kurtz D.M., Alig S.K., Frank M.J., Shukla N., Garofalo A., Macaulay C.W., Shahrokh Esfahani M., Olsen M.N., Hamilton J., Hosoya H., Hamilton M., Spiegel J.Y., Baird J.H., Sugio T., Carleton M., Craig A.F.M., Younes S.F., Sahaf B., Sheybani N.D., Schroers-Martin J.G., Liu C.L., Oak J.S., Jin M.C., Beygi S., Huttmann A., Hanoun C., Duhrsen U., Westin J.R., Khodadoust M.S., Natkunam Y., Majzner R.G., Mackall C.L., Diehn M., Miklos D.B., Alizadeh A.A