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Further investigation allowed to identify that the peripheral blood memory B cell population was altered in sarcoidosis patients compared to healthy subjects due to the decreased levels of “unswitched” (IgD + CD27+) and “class-switched” (IgD − CD27+) memory B cells, whereas the levels of CD19 + CD24+++CD38+++ and CD19 + CD5 + CD27– regulatory B cells were increased (42)

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It has also been proven that the supply of silymarin, a well-known compound with antioxidant properties extracted from the edible plant Silybum marianum [119,120], can help in terms not only of antioxidant effect, but also anti-inflammatory and antifibrotic effect [121]

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