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21 Oxidative Stress Marker Measurement Oxidative stress markers F 2 -isoprostanes (F 2 -IsoP) and their major metabolite 2,3-dinor-5,6-dihydro-15-F 2t -IsoP (F 2 -IsoP-M) in urine were measured by using gas chromatography/negative ion chemical ionization mass spectrometry (GC/NICI MS) at the Vanderbilt Eicosanoid Core Laboratory

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These effects were observed in APPswe/PSEN1dE9 mice with a C57BL/6 background treated with 100 mg/kg for 30 days, demonstrating its potential role in vascular health and AD symptom management (Kaushik et al., 2018)