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The results mentioned above, along with the strong association between GPX7 and several immunosuppressive cells (e.g., NKT cells, TAMs, and MDSCs) or inhibitory immune checkpoint markers (e.g., PD-1, CTLA-4, LAG-3, TIGIT, TIM-3 and CD96 ) further enhances the importance of GPX7 in the regulation of an immunosuppressive tumor microenvironment 158,159,160,161,162

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TB-500 reconstitution follows a similar protocol: 1–2 mL of bacteriostatic water per 5 mg vial