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Generally, HO-1 levels remain low across diverse tissues except for the spleen, but diverse stimuli (like hydrogen peroxide, UV radiation, endotoxins, and hypoxia) can cause a strong inducible response for shielding cells from damaging oxidative and inflammatory agents [34]

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The activity of CYP enzymes can be inhibited or induced by other xenobiotics, as well as foods (Zhao et al., 2021)