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The mechanism underlying taurine's action in maintaining [Ca 2+ ] i homeostasis is at least partly through its inhibition of [Ca 2+ ] i influx by preventing the reverse mode of Na + /Ca 2+ exchangers [98]

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A meta-analysis published in 2023 that included this trial and four other treatment trials conducted since that time concluded that duloxetine is only associated with a modest trend toward pain reduction and that this is accompanied by a similar trend in increased adverse events, suggesting a need for additional well-designed trials to support its continued use in this setting (Chow 2023)

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