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LIST OF ABBREVIATIONS 3-NP 3-nitropropionic acid ACh Acetylcholine AChE Acetylcholine Esterase AD Alzheimer’s Disease AED Anti-Epileptic Drugs Akt Protein kinase B ALCAR Acetyl-L-Carnitine APP Amyloid Precursor Protein APP Amyloid Precursor Protein BACE Beta-site APP Cleaving Enzyme BAD Bcl-2-Associated Death promoter Bax Bcl-2-like protein 4 Bcl-2 B-cell lymphoma-2 Bcl-W Bcl-2-like protein Bcl-xL B-cell lymphoma-extra-large BDNF Brain Derived Neurotrophic Factor BIM Bcl-2-like protein 11 BM Bacopa monnieri BMP Petasites japonicum CA Cornuammonis CA Carnosicacid CK Creatine Kinase CNS Central Nervous System COX-2 Cycloxygenase-2 CREB cAMP Response Element Binding protein DA Dopamine DOPA Dihydroxyphenylalanine ER Estrogen Receptor ERK Extracellular signal-Regulated Kinases FAO Food and Agriculture Organisation GABA Gamma aminobutyric acid GPER G Protein-Coupled Estrogen Receptor GSH-Px Glutathione peroxidase GSK3β Glycogen synthase kinase 3 beta GTS Ginsenosides Total Saponins HD Huntington’s Disease HIV Human Immunodeficiency Virus HSYA Hydroxysafflor Yellow A IFN-𝛾 Interferon gamma IGF Insulin-like Growth Factor IL-1 Interleukin-1 iNOS Inducible Nitric Oxide Synthase JNK c-Jun amino-terminal Kinase L-DOPA Levo-dihydroxyphenylalanine LD Lethal Dose LDH Lactate Dehydrogenase MAO Monoamine Oxidase MAPK Mitogen-Activated Protein Kinase MeSH Medical Subject Heading MCA Middle Cerebral Artery MDA Malondialdehyde MES Maximal Electroshock MID Multi-Infarct Dementia MPTP 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine NAC N-Acetyl-Cysteine NF-𝜅B Nuclear Factor-kappa B NGF Nerve Growth Factor NO Nitric Oxide OS Oxidative Stress PD Parkinson’s Disease PI3K Phosphoinositide 3-Kinase PNS Peripheral Nervous System PTZ Pentylenetetrazole Ras Retrovirus-Associated DNA Sequences ROS Reactive Oxygen Species SD Sprague Dawley SDH Succinic Acid Dehydrogenase SN Substantia Nigra SOD Superoxide Dismutase SYB Hydroxysafflor Yellow B THLE Tonic Hind Limb Extensor TNF Tumor Necrosis Factor TUNEL Terminal deoxy nucleotidyl transferase-mediated dUTP-biotin nick end labelling VGSC Voltage-Gated Sodium Channel WHO World Health Organization CONSENT FOR PUBLICATION Not applicable

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Spectroscopic evidence for site specific chemistry at a unique iron site of the [4Fe–4S] cluster in ferredoxin:thioredoxin reductase