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Here, we start with protonation of the nitrogen (Step 4, arrows G and H) followed by tautomerization, where a C-O pi bond forms and the C-N pi bond breaks (Step 5, arrows I and J)

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2.2 Pharmacokinetics and dosing regimens The pharmacokinetics and dosing regimens of Bevacizumab in OC treatment have been increasingly defined through clinical trials

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