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10.1016/j.numecd.2024.08.015 212 SzkudlinskaM

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252,253 Platelets contain calpains, which are calcium-dependent, sulfhydryl-containing, neutral proteases composed of two subunits that preferentially cleave cytoskeletal proteins, in particular filamins and talin, 229,254 but have also been reported to cleave the cytoplasmic domain of integrin β 3 , and a number of molecules involved in signaling, including kinases and phosphatases (see “Calcium-Dependent Proteases [Calpains]” below)