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Engagement of β-glucans with Dectin-1 triggers tyrosine phosphorylation of an immunoreceptor tyrosine activation (ITAM)-like motif, which in turn recruits and activates the Syk tyrosine kinase, leading to activation of both NF-κB and MAPKs through a signaling pathway mediated by Card9 and Raf (9, 12–14)

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Systemic therapy for hepatocellular carcinoma, from the early to the advanced stage: a Japanese perspective