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“Tramadol is not a magic bullet – on average, it provides only modest pain relief, and it carries real risks, including nausea, dizziness, constipation, and, in rare cases, more serious complications like cardiac events or seizures,” Chang said

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After multivariable adjustment using Cox regression, ANA-positivity was associated with faster ALT normalization (HR 1.32, 95% CI 1.00-1.73, p=0.047) and SMA-positivity was associated with slower ALT normalization (HR 0.63, 95% CI 0.46-0.85, p=0.003) (Figure A)

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