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You should not take Contrave® if you: Have uncontrolled high blood pressure Have anorexia or bulimia Have or have had seizures Use other medicines that contain bupropion such as Wellbutrin®, Wellbutrin® SR, Wellbutrin® XL, Aplenzin®, or Zyban® Are undergoing an abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs Drink a lot of alcohol and abruptly stop drinking Have kidney disease Have liver disease (it may cause liver dysfunction or hepatitis) Are depressed or have suicidal feelings Have current or recent (within the past 7-14 days) use of opioids or opiate drugs You should not take Contrave® under these circumstances either: If you’re pregnant, breastfeeding, or planning to become pregnant If you’ve taken an MAOI (monoamine oxidase inhibitor), such as Nardil®, Parnate®, or Marplan® in the past 14 days If you’re taking any opioids or opiate drugs If you’re dependent on opioids or using methadone or buprenorphine If you are in opioid withdrawal If you take opioids or opiates right after stopping Contrave®, you may be more sensitive to them and require lower doses—which poses a risk of overdose
