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For example, the potent NRF2 inducers based on the triterpenoid scaffold, like CDDO, can bind to over 500 cellular proteins, including mTORC1, AMP-activated protein kinase (AMPK), and IKK, which may result in pleiotropic effects in cells (140, 153)

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Wei, F., Urashima, S., Nihonyanagi, S