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Intermediate metabolizer—A person whose ability to break down the drugs is reduced/slower than what is expected

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however, given the imprecision in study results and imbalances in the distribution of DPYD variants between groups, it is uncertain whether genotype-guided dose reduction in heterozygous DPYD carriers led to a lower risk of severe toxicity and toxicity-related hospitalization than that of carriers treated with a standard dose (GRADE: Very low)