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On this basis, Rayman proposed that 122 µg/L represents the concentration of baseline serum selenium that “delineates a change in risk, from lower to higher, of developing cancer and type 2 diabetes in patients treated with selenium supplementation of 200 µg per day” ( Selenium supplements contain sodium selenite or selenomethionine, and the main difference between them is that, after saturation of selenoproteins, selenite is excreted whereas selenomethionine can further increase serum selenium through its incorporation into proteins ( Use of Selenium in GH Based on the above described role of oxidative stress in GH and the antioxidant activity of selenium, clinical studies were performed to investigate its effect in GH patients