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Keywords: Copper, Hepatic steatosis, Mechanism, Metabolic dysfunction-associated steatotic liver disease, Wilson's disease Core Tip: Hepatic steatosis diseases are strongly associated with copper, and it has been shown that copper levels promote hepatic fat synthesis or lipolysis by triggering different mechanisms, which is extremely important for unravelling the molecular mechanisms of hepatic steatosis in diseases such as metabolic dysfunction-associated steatotic liver disease and Wilson's disease