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Pharmaceutical Vial Nomenclature, Capacity, and Standards ISO 8362-1:2025 establishes standardized "R" designations correlating brimful capacity with critical dimensions essential for automated filling, crimp sealing, and syringe reconstitution: Type I borosilicate glass construction per USP 660 prevents hydrolytic leaching that destabilizes peptide charge states during reconstitution with bacteriostatic water (0.9% benzyl alcohol)