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In another study, B-GOS supplementation was compared to placebo in healthy participants and found to decrease waking salivary cortisol concentrations and increase the positive processing of information in a dot-probe task (485)

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Given that the SAM is the universal methyl donor for methylation of substrates including proteins, nucleotide acids and lipids, the NNMT induced methyl sink in the form of MNA impairs the genome methylation