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Cramer and Jay (286) later demonstrated the independent effect of body mass by comparing deep body temperature responses to cycling exercise at fixed absolute rates of heat production between groups of heavier (mean: 91.5 kg) and lighter (mean: 67.6 kg) individuals matched for age, sex, and heat acclimation status

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Pyridoxine phosphate oxidase (PNPO) synthesizing PLP requires riboflavin as its main cofactor (65)