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For instance, animals with disrupted microbiota exhibit enhanced microglial activation, synaptic deficiencies, and cognitive impairment (Krishnapriya et al., 2025) This effect appears to be sex-dependent and can originate as early as prenatal development, where microbiome alterations are linked to abnormal microglial maturation (Thion et al., 2018)

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(2011) Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine–copper complex