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Although the HBD of SOD3 does not participate in the enzymatic activity of SOD3, its HBD region is required for binding to type I collagen and LDL receptor-associated proteins, which are absorbed and internalized into cells via adhesion proteins and low-density protein receptor-associated proteins (LRP)-mediated endocytosis pathways

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doi: 10.1159/000508971 49 YangCWuXLiuJWangHJiangYWeiZet al