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81 In females, Vitamin A, carotenoids, resveratrol, and quercetin have been demonstrated to enhance the activity of endogenous antioxidant enzymes (SOD, CAT, GPx, and GR) in the ovary by stimulating the Nrf2 signaling pathway to increase the expression of these enzymes

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Notably, nuciferine, the primary bioactive compound isolated from lotus leaf, can prevent iron accumulation and lipid peroxidation in folic acid-induced AKI by enhancing intracellular GSH and GPX4 levels, ultimately inhibiting ferroptosis (166)