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In line with Cuccurazzu’s findings, Nasca and colleagues proposed that LAC promotes rapid antidepressant responses, at least in part, via epigenetic mechanisms that may involve acetylation of histone proteins and NF-κB p65, activating in turn mGlu2 receptor and BDNF gene expression

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Finally, the tight connections between ferroptosis, oxidative stress, immune responses, and metabolic regulation make it difficult to isolate its exact role in disease progression