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According to our findings in the present and previous [17] studies, it takes a certain time for p38 and Nrf2 to be activated by quercetin and for gene transcription and protein expression of Nrf2 target proteins (MRP-1, GCLC and GCLM) to be induced, with maximal protein expression observed after 18 h of incubation

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GHK-Cu binds to copper ions and delivers them to skin cells, activating pathways involved in cell renewal, wound repair, and anti-inflammatory response