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Interestingly, nearly all these flavonoids reduce inflammatory mediators such as tumor necrosis factor-alpha (TNF-α), nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1 beta (IL-1β), interleukin-18 (IL-18), and interleukin-6 (IL-6) (Jeong et al., 2015

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These formulations combine Vitamin C with B vitamins, electrolytes, amino acids, or antioxidants like Glutathione