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named this phenomenon “autosis” after observing it while treating HeLa cells with the autophagy-specific activator Tat-Beclin1 [73]

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The ROS produced under these conditions, primarily superoxide and its downstream product hydrogen peroxide (H₂O₂), act locally within astrocytes to modulate transcription factors such as Nrf2, which regulates the expression of antioxidant enzymes including glutathione peroxidase and superoxide dismutase (Vicente-Gutierrez et al, 2019)