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385 Astrocytic overload with mercury causes cell swelling, it severally impairs glutamate uptake, K + buffering and glutathione production, 386 this causing secondary excitotoxicity and oxidative damage to neurones

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DIO2, in particular, enables local T3 generation in astrocytes and tanycytes, ensuring brain regions maintain sufficient hormone activity even during systemic fluctuations (57, 128)

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