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472 Notably, a selective HDAC8 inhibitor PCI-34051 was found to stimulate antitumor immunity, and mice treated with combination of PCI-34051 and anti-PD-L1 antibody were safeguarded against subsequent tumor rechallenge and stayed tumor-free for over 15 months

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A single treatment of mice 42 days post infection (d.p.i.) with 1 (100 mg/kg i.p.) resulted in a 44% decrease in worm and a 40% reduction in egg burdens, respectively