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(2018) showed that compared to wild-type mice, SHANK3- and SHANK2-knockout mice had fewer glutamate receptors in the striatum and thalamus regions, while CNTN4 knock-out mice had fewer glutamate receptors in the cortex and hippocampus regions [60]

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Finally, pro-caspase 9 has been shown to get activated by mitochondrial cytochrome c (which has been shown to be increased in ES) [204] also linking oxidative stress and mitochondrial functioning to apoptosis