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For example, rosiglitazone and pioglitazone, two thiazolidinediones (TZD) drugs, are able to induce phenotype switching in microglia via suppressing mitogen-activated protein kinase (MAPKs) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) [72], leading to a significant reduction in infarct volume and improved neurological function [73, 74]