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Figure 3 3.2 UPF and depression 3.2.1 Background on known mechanisms of depression One of the most widely recognized pathophysiological mechanisms involved in the development of mood disorders, such as depression, is the monoamine hypothesis ( Another model is the stress-diathesis theory, which suggests that stressful events during life can alter neuroplasticity and transmission, which leads to the symptoms of major depression ( Depression risk is also a combination of genetic and environmental factors ( 3.2.2 Implications of UPF consumption on depression risk Previous studies have demonstrated a significant association between UPF and depression, which remains after adjusting for a range of confounders (Table 1)