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A second nitric-oxide-linked pathway was reported by the same group in isolated vessel preparations, where increased Src and caveolin-1 phosphorylation coincided with reduced eNOS to caveolin-1 binding and a measured 1.35-fold increase in endothelial nitric oxide production

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In addition, structural comparison of GHSR in complex with different G protein subtypes elucidated the mechanisms driving G protein selectivity