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ROS can also disturb protein folding within the ER lumen by altering the redox balance of disulfide bond formation, further activating the unfolded protein response (UPR) via PERK, IRE1, and ATF6 sensors (77)

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Astragalus contains saponins, polysaccharides, flavonoids, trace elements, and amino acids, which can scavenge free radicals to regulate immune functions [147]