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Why Acetaminophen Toxicity Matters for the USMLE • High-Yield Pathophysiology: Overdose exhausts normal hepatic metabolic pathways, leading to accumulation of the toxic metabolite NAPQI. Glutathione initially inactivates NAPQI, but once depleted, NAPQI

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• Avoid NSAIDs in patients with peptic ulcer disease, renal failure, or bleeding disorders