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When thinning is not autoimmune in origin, these scalp nutrient injections can serve as a first step before more advanced treatments

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When R-spondin 2 was added to explant cultures from wildtype mice, the number of outer hair cells decreased modestly, further indicating that R-spondin 2 has the opposite effect of β-catenin activation in the developing cochlea and do not appear to potentiate canonical Wnt signaling to increase the number of hair cells (Jacques et al., 2012