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TRP channels are expressed across multiple cell types implicated in rosacea, including sensory neurons, MCs, endothelial cells, and keratinocytes ( 4 Immune dysregulation 4.1 Innate immune dysregulation 4.1.1 LTR2/LL37 pathway Toll-like receptor 2 (TLR2), a pattern recognition receptor (PRR), activates the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) ( Inflammasomes are multiprotein complexes of the innate immune system that trigger inflammatory responses through caspase-1 activation