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Together, these results demonstrate that reprogramming BoNT/X protease to cleave gasdermin D is achievable through iterative substrate design, negative selection and circuit optimization

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Quercetin-3-glucoside (isoquercetin), a glycosylated derivative of quercetin, enhances antioxidative defenses by activating Nrf2 and mitigating UVB-induced damage, making it relevant for managing both pigmentation disorders and melanoma 145,146