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In melasma, the reduction of mMASI by treatment with a broad-spectrum sunscreen and topical TC is expected to be 30–40% after 8 weeks and 50–60% for 16 weeks [35–37]

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doi: 10.3389/fimmu.2022.913854 169 KhanMZLiuLZhangZKhanAWangDMiSet al