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Concussions are often described as “mild” traumatic brain injuries, but metabolically, there’s nothing mild about them

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Based on the finding that Cu chelator exhibit a potent suppression effect on Cu-induced cell death, it would be important to carry out appropriate Cu-deprivation strategies to reduce the level of intracellular Cu 2+ ion in Cu-overload conditions, for example, using a Cu chelator, reducing dietary Cu intake, and/or genetically modifying Cu transporters