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During AD, an uncoupling between the insulin receptor (IR) and the insulin receptor substrate 1 (IRS1) occurs as a consequence of the downregulation of IR expression and/or the inactivation of IRS proteins leading to the inability of insulin to promote its normal cellular downstream outcomes

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[DOI] [PubMed] [Google Scholar] 84.Tremblay R., Bonnardeaux A., Geadah D., Busque L., Lebrun M., Ouimet D., Leblanc M