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J Immunol (2009) 182(9):5800–9.10.4049/jimmunol.0801873 31 ZhangXWheelerDTangYGuoLShapiroRARibarTJet alCalcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages

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It was first isolated in 1973 by biochemist Loren Pickart, who observed that serum from younger people could regenerate certain types of cells — and that GHK-Cu was one of the key molecules responsible