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The production, folding, quality control, and post-translational modification of secretory and transmembrane proteins occur in ER and its function is critically affected by changes in extracellular–intracellular environment like hypoxia, pH change, nutrient deprivation, aberrant disulfide bond formation, protein overexpression, asparagine (N)-linked glycosylation inhibition, calcium ion depletion, and changes in redox status resulting in ER stress [130,131,132]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Fernandez-Fernandez S., Almeida A., Bolaños J