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Depending on the experimental setting and IGF function being assessed, IGFBPs may potentiate or inhibit IGF activity in the gastrointestinal tract primarily by altering the interaction of IGF-I or IGF-II with the IGF-IR

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RSV- and TNS-loading nanoparticles, separately targeting LSECs and HSCs, were made, and their synergistic effect on HCC growth was assessed in mouse fibrotic HCC model