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Although low vitamin B12 levels did not have a significant predictive value for EDS, there was a significant correlation between low vitamin B12 levels and EDS in obese patients (BMI ≥ 30) (OR = 3.996, 95% CI = 1.006–15.876, p = 0.039)

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A systematic review and meta-analysis with 9 RCTs found that compared with the medicine-treated group, EA significantly improved the frequency of spontaneous gastrointestinal movements, total response rates and reductions in symptoms score, indicating that EA was more effective and safer than medication in CFC patients 133 , 134