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Adipocyte-specific basic region-leucine zipper (B-ZIP) transcription factor knockout mice, which are called A-ZIP/F-1 fatless mice due to a lack of white fat tissue, are hyperinsulinemic and hyperglycemic, due to severe defects in IRS-1 and -2 associated PI3K activity in muscle and liver [95,96]

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Meta-analyses suggest berberine may have modest effects on body weight compared to placebo over 8–12 weeks, alongside improvements in fasting glucose and lipid profiles